Researchers claim to have used the Nobel Prize-winning Crispr gene-editing technology to eliminate HIV from infected cells, likening its function to molecular scissors that can cut out or deactivate undesirable DNA segments. While existing HIV medications can suppress the virus but not eradicate it, this new approach aims to completely rid the body of HIV. However, it's emphasized that this is still in the early stages and more research is required to ensure its safety and effectiveness.
The University of Amsterdam team presented their preliminary findings at a medical conference, highlighting that their work is currently a "proof of concept" and not a cure for HIV. Dr. James Dixon of the University of Nottingham agrees, noting that further investigation is needed to validate the results in a whole-body context for potential therapeutic application.
Despite some positive results, challenges remain. Dr. Jonathan Stoye of the Francis Crick Institute points out that completely removing HIV from all potential reservoirs in the body is exceedingly difficult. Concerns about off-target effects and long-term side effects also persist, suggesting that it may take many years before Crispr-based therapy for HIV becomes routine, assuming its efficacy can be demonstrated.
HIV infects and damages immune cells, including those in a latent state that still harbor HIV DNA. While some individuals have been seemingly cured after aggressive cancer therapy, this approach isn't feasible solely for treating HIV. Therefore, the quest for an effective and safe cure or long-term treatment for HIV remains ongoing.