Pope Boniface V, the sixty-ninth Pope of the Holy See, was known for his generosity, charitable works, and policies that favored the diocesan clergy. His papacy also marked significant actions in the Church of England and the conversion of King Edwin of Northumbria.

Like his predecessor, Pope Boniface V was elected by a clergy class. Like Pope Adeodatus I, Pope Boniface had to wait about a year for royal approval of his election. After receiving the emperor's approval and consent, he was consecrated Bishop of Rome and the sixty-ninth Pope of the Holy See on 23 December AD619.

Pope Boniface V took special care to implement policies that favored the diocesan clergy. He restricted the authority to bear the relics of martyrs to the bishops.

The Pontiff also took a special interest in the Church of England.

As a sign of his special interest, when Bishop Justus was elected Archbishop of Canterbury in 624, Pope Boniface bestowed upon him the pallium, which symbolized the pastoral authority of bishops. In a special letter, Pope Boniface urged King Edwin of Northumbria to learn more about the Catholic faith and to embrace it. He also asked Queen Ethelburga, who was a Catholic, to work for the conversion of King Edwin and his subjects.

After the demise of Pope Boniface, King Edwin converted to Catholicism.

Pope Boniface V began the practice of establishing asylums in churches. He was known for his generosity and charitable works. He was a lifelong supporter of the poor. Like his predecessor, he distributed his inheritance to the clergy.

In A.D. 625, Pope Boniface V passed away on 25 October and was laid to rest in St. Peter's Basilica.

Pope Boniface V's epitaph describes him as "generous, wise, pure, ingenuous, and just."